Relief of symptoms of advanced thromboangiitis obliterans (Buerger's disease) w/ critical limb ischemia in cases where revascularization is not indicated. Relief of symptoms of severe peripheral arterial occlusive disease (PAOD stage III, IV), particularly those at risk of amputation & in whom surgery or angioplasty is not possible. Relief of symptoms of severe disabling Raynaud's phenomenon unresponsive to other therapies.
Dosage/Direction for Use
Adjust dose according to individual tolerability w/in the range of 0.5-2 ng/kg body wt/min over 6 hr daily by IV infusion for up to 4 wk. Duration of treatment for Raynaud's phenomenon: 3-5 days.
Contraindications
Active peptic ulcers, trauma, intracranial hemorrhage; severe CHD or unstable angina; MI w/in the last 6 mth; acute or chronic CHF; arrhythmia relevant to the prognosis; suspected pulmonary congestion. Pregnancy & lactation.
Special Precautions
Hypotension. Possible orthostatic hypotension. Monitor patients w/ significant heart disease. Avoid contact w/ skin or mucous membranes.
Adverse Reactions
Flush, headache, GI symptoms, sweating, nervous system & psychiatric disorders, infusion site reactions.
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